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PATHOGENES12 - PATHOGENESIS Treponema pallidum is capable...

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PATHOGENESIS: Treponema pallidum is capable of infecting all body tissues. The disease caused by T. pallidum is syphilis. This is a relatively painless, slowly evolving disease. The host- parasite relationship leads to short symptomatic periods when the organism multiplies, followed by prolonged asymptomatic periods when host responses produce healing. Syphilis is strictly a person-person disease. An incubation period of from 10 to 90 days precedes the clinical presentation, despite the fact that the organisms disseminate immediately. The prominent feature of the disease is vascular involvement, particularly arterioles and capillaries. Treponemal antigen-host antibody complexes may cause some immunosuppression of the host and production of the distinct clinical stages: o The primary stage occurs weeks to months following infection. The principal sign of infection is the hard chancre, generally found on the genitals. This lesion is
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