PATHOGENES13 - meningitis in children aged 6 months-2 years...

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PATHOGENESIS: The organisms colonize the nasopharynx and are spread by direct contact. Haemophilus are capable of penetrating the epithelium to produce a bacteremia that may lead to localization of the organisms in many organs. The capsule is Haemophilus ' major virulence determinant yet unencapsulated strains produce ear, sinus and respiratory infections. H. influenzae type b is the most common cause of bacterial
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Unformatted text preview: meningitis in children aged 6 months-2 years. It is uncommon in adults because of protective antibody. • Cellulitis, conjunctivitis, epiglottitis and arthritis may also result from Haemophilus infection. • For pneumonia in adult men, unencapsulated H. influenzae is second only to the pneumococcus ( S. pneumoniae ). Those affected are usually chronic smokers, alcoholics or elderly....
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