PATHOGENES13 - meningitis in children aged 6 months-2...

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PATHOGENESIS: The organisms colonize the nasopharynx and are spread by direct contact. Haemophilus are capable of penetrating the epithelium to produce a bacteremia that may lead to localization of the organisms in many organs. The capsule is Haemophilus ' major virulence determinant yet unencapsulated strains produce ear, sinus and respiratory infections. H. influenzae type b is the most common cause of bacterial
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Unformatted text preview: meningitis in children aged 6 months-2 years. It is uncommon in adults because of protective antibody. Cellulitis, conjunctivitis, epiglottitis and arthritis may also result from Haemophilus infection. For pneumonia in adult men, unencapsulated H. influenzae is second only to the pneumococcus ( S. pneumoniae ). Those affected are usually chronic smokers, alcoholics or elderly....
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