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PATHOGENES14 - HOST DEFENSES • Antibody against the...

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PATHOGENESIS: Whooping cough results from colonization and multiplication of Bordetella pertussis on the mucus membranes of the respiratory tract, in particular, the ciliated epithelial cells. Production of toxins irritates cells causing ciliostasis and leukocytosis. The hallmark of pertussis is the spasmatic cough that may last 6 weeks. Occasional secondary complications include encephalopathy, seizures and pneumonia.
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Unformatted text preview: HOST DEFENSES: • Antibody against the pertussigen exotoxin affords immunity. EPIDEMIOLOGY: • The mucus membranes of the respiratory tract are the organism's natural habitat. • Disease generally follows direct contact with an infected person. • Pertussis is generally a disease of infants (50% of cases occur in children less than 1 year old). • The disease is highly contagious....
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