PATHOGENESI1 - PATHOGENESIS: C. perfringens: Gas gangrene...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
PATHOGENESIS: C. perfringens : Gas gangrene results from an anaerobic tissue environment caused by poor blood supply due to trauma, surgery, etc. This acute disease is often fatal. One to six days following trauma, a generalized fever and pain is observed in the affected area. This leads to rapid muscle necrosis because of the release of bacterial exotoxins (lecithinases, hemolysins, collagenases, proteases, lipases). A spreading infection ensues. Gas gangrene generally involves muscle extremities where anaerobiosis can occur. C. tetani : Tetanus results from trauma or a puncture wound leading to tissue contamination. Tetanus is a non-invasive disease occurring because of the release of exotoxins. C. tetani produces a spasmogenic toxin that fixes to gangliosides thereby blocking the release of the neurotransmitter glycine. Glycine normally prevents contraction of antagonistic muscles; therefore, muscle spasms and convulsions (lockjaw) may occur. Cardiac failure can lead to death in approximately 55-65% of
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/05/2011 for the course BIOLOGY MCB2010 taught by Professor Jessicadigirolamo during the Fall '10 term at Broward College.

Page1 / 2

PATHOGENESI1 - PATHOGENESIS: C. perfringens: Gas gangrene...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online