PATHOGENESI3 - immune response(autoantibodies...

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PATHOGENESIS: S. pyogenes is the leading cause of bacterial pharyngitis and tonsillitis. It may also produce sinusitis, otitis, arthritis and bone infections. Some strains prefer skin, producing either superficial (impetigo) or deep (cellulitis) infections. S. pneumoniae is the major cause of bacterial pneumonia in adults. Its virulence is dictated by its capsule. Post-infection sequelae of S. pyogenes occur 1-3 weeks after acute disease. These sequelae include i) acute rheumatic fever (following pharyngeal infections) and ii) glomerulonephritis (following either pharyngeal or skin infections). These sequelae may be due to an altered
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Unformatted text preview: immune response (autoantibodies). Glomerulonephritis results from deposition of Ag:Ab complexes on basement membrane of kidney glomeruli. • Other species/groups include: o Group B strep (e.g. S. agalactiae ) most often produce disease in animals but are also the leading cause of neonatal septicemia and meningitis. o Group D strep (e.g. E. faecalis ) produce urinary tract infections and endocarditis. o Viridans species (e.g. S. mutans ) are responsible for oral caries and subacute bacterial endocarditis following dental surgery. o Anaerobic streptococci may cause genital, brain or abdominal infections....
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This note was uploaded on 11/05/2011 for the course BIOLOGY MCB2010 taught by Professor Jessicadigirolamo during the Fall '10 term at Broward College.

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