PATHOGENESI4 - multiplication followed by viremia A...

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PATHOGENESIS: Parainfluenza: These viruses generally produce local infections in the upper and lower respiratory tract. The viruses implant in ciliated epithelia of respiratory tract (nose and throat). The virus can be shed over 3-16 days and the main pathologic response is inflammation. The most important (i.e. serious) diseases are croup, bronchiolitis and pneumonia. The severe diseases occur most often with types 1 and 2. Mumps: Mumps is a systemic infection spread by viremia. The major targets include glandular and nervous tissue. The virus enters via the pharynx or conjunctiva, there is local
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Unformatted text preview: multiplication followed by viremia. A secondary viremia disseminates the virus to salivary glands, testes, ovaries, pancreas and the brain. The incubation period is 18-21 days and disease is asymptomatic in about 35% of those infected. The most characteristic response is painful enlargement of the parotid glands. Severe cases may progress to include epididymoorchitis in prepubescent males, which can cause atrophy of the testes, but rarely sterility. Mumps can also produce a transient high frequency deafness....
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