{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

PATHOGENESI6 - 1 Chronic persistent Infections are...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
PATHOGENESIS: Hepatitis A: Clinical presentation of HAV infection varies from subclinical and mild in children to jaundice in adults. The virus usually enters by intestinal infection (fecal-oral transmission), spreads via the blood to the liver, which is its target organ. HAV is detectible in the feces during the incubation period (average 4 weeks), preceding a rise in serum levels of aminotransferase enzymes and the occurrence of pathologic changes in the liver. Most disease resolves within two weeks. Chronicity or fulminant hepatitis is rare. Hepatitis B: HBV, in contrast, may produce a persistent carrier state in addition to liver damage. Infection early in life often produces a carrier state, but only about 5-10% of cases if infection occurs later . Most disease is acquired via the parenteral route (blood transfusions. There are generally two patterns of HBV-associated disease:
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 1. Chronic persistent: Infections are generally asymptomatic with a mild elevation of serum alanine transaminase (ALT) and little liver fibrosis. 2. Chronic active: Infections produce jaundice with elevated ALT levels, liver damage and cirrhosis. Liver failure may predispose those affected to cancer . • Hepatitis C: HCV may also produce a persistent carrier state, a higher level of chronic disease and cirrhosis. At least 50% of HCV infections result from blood transfusion. • The following table outlines some of the differences between the Hepatitis viruses: Hepatitis A Hepatitis B Hepatitis C Genome +RNA DNA +RNA Onset Abrupt Insidious Insidious Transmission Fecal-Oral Parenteral Parenteral Incubation (days) 15-40 60-180 28-112 Asymptomatic infection usual common common Carrier State no yes yes Chronicity 0% 10% 30-60% Sequelae no cirrhosis cirrhosis...
View Full Document

{[ snackBarMessage ]}

Page1 / 2

PATHOGENESI6 - 1 Chronic persistent Infections are...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon bookmark
Ask a homework question - tutors are online