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PATHOGENESI7 - Infection results via the nasopharynx by...

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PATHOGENESIS: Polioviruses: A number of syndromes can be observed, most (90-95%) are subclinical. About 4-8% present with a mild fever, sore throat and headache. Nonparalytic polio occurs in about 1% of cases while paralytic disease affects only 0.1%. Of the paralytic conditions, about 5-10% affect the cranial nerve or medulla while the others are spinal and limited to muscle weakness rather than complete paralysis. Coxsackievirus, Echovirus: Infection by Coxsackie- or Echoviruses resembles that produced by Poliovirus. A variety of syndromes are possible, ranging from trivial to severe. Rhinovirus:
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Unformatted text preview: Infection results via the nasopharynx by direct contact. Viral replication leads to inflammation and edema, symptoms of the common cold. Inapparent infection is common. HOST DEFENSES: • Enteroviruses: Interferon is effective against these viruses. More specifically, IgA antibodies in the intestine and saliva are protective. • Rhino: Susceptibility to the Rhinoviruses is dependent on prior exposure. Antibody of the IgA and IgG classes is important. Non-specific defenses including interferon, gastric acidity and temperature may play a major role in controlling infection....
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