PATHOGENESI8 - PATHOGENESIS: Herpesviruses infect a range...

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PATHOGENESIS: Herpesviruses infect a range of different cell types, causing different disease scenarios. The skin and mucus membranes are common sites of infection for HSV and VZV; CMV and EBV are more internal (EBV infects B lymphocytes). The viruses produce intranuclear inclusions and multinucleated giant cells With the exception of VZV, primary Herpes infections are often asymptomatic. The process of latency is poorly understood but, except for VZV, asymptomatic shedding is common. Recurrence of acute disease results because of emotional stress, surgery, trauma, cold, fever, immune suppression, etc. Recurrence of HSV is common, frequent and localized. More specifically: o HSV-1 is responsible for a variety of infections. Most commonly, HSV-1 produces the condition known as gingivostomatitis in which oral cavity vesicles or ulcers form . These lesions may recur frequently as "cold sores" (herpes labialis). Another condition produced by HSV-1 is herpetic keratitis, which may be
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PATHOGENESI8 - PATHOGENESIS: Herpesviruses infect a range...

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