PATHOGENESIS - Salmonella enteritidis is the most common...

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PATHOGENESIS: Salmonellosis may present as one of several syndromes including gastroenteritis, enteric (typhoid) fever or septicemia. Disease is initiated by oral ingestion of the bacteria followed by colonization of the lower intestine. The bacteria are capable of mucosal invasion, which results in an acute inflammation of the mucosal cells. This then leads to the activation of adenylate cyclase, increased fluid production and release of fluid into the intestinal lumen, resulting in diarrhea. Salmonella gastroenteritis is the most common form of salmonellosis and generally requires an 8-48 hour incubation period and may last from 2-5 days. Symptoms include nausea, vomiting and diarrhea.
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Unformatted text preview: Salmonella enteritidis is the most common isolate. Enteric or typhoid fever occurs when the bacteria leave the intestine and multiply within cells of the reticuloendothelial system. The bacteria then re-enter the intestine, causing gastrointestinal symptoms. Typhoid fever has a 10-14 day incubation period and may last for several weeks. Salmonella typhi is the most common species isolated from this salmonellosis. Salmonella septicemia (bacteremia) may be caused by any species but S. cholerae-suis is common. This disease resembles other Gram-negative septicemias and is characterized by a high, remittent fever with little gastrointestinal involvement....
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