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Unformatted text preview: morphology and replicate in the host cytoplasm. Poxviruses cause localized and generalized infections in humans and animals. Smallpox was the major human disease agent but it was officially declared eradicated by the World Health Organization (WHO) in 1980. Smallpox is transmitted via the respiratory route. In the body, it is spread by a transient viremia to internal sites, and then a second viremia to the skin where the characteristic lesions erupt. The lack of an animal reservoir made eradication of human disease possible....
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