REGULATION OF THE HUMORAL RESPONS1

REGULATION OF THE HUMORAL RESPONS1 - interactions with...

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REGULATION OF THE HUMORAL RESPONSE Regulation of the immune response is possibly mediated in several ways. First, a specific group of T-cells, suppressor T-cells, are thought to be involved in turning down the immune response. Like helper T-cells, suppressor T-cells are stimulated by antigen but instead of releasing lymphokines that activate B-cells (and other cells), suppressor T-cells release factors that suppress the B-cell response. While immunosuppression is not completely understood, it appears to be more complicated than the activation pathway, possibly involving additional cells in the overall pathway. Other means of regulation involve interactions between antibody and B-cells. One mechanism, "antigen blocking", occurs when high doses of antibody interact with all of the antigen's epitopes, thereby inhibiting
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Unformatted text preview: interactions with B-cell receptors. A second mechanism, "receptor cross linking", results when antibody, bound to a B-cell via its Fc receptor, and the B-cell receptor both combine with antigen. This "cross-linking" inhibits the B-cell from producing further antibody. Another means of regulation that has been proposed is the idiotypic network hypothesis. This theory suggests that the idiotypic determinants of antibody molecules are so unique that they appear foreign to the immune system and are, therefore, antigenic. Thus, production of antibody in response to antigen leads to the production of anti-antibody in response, and anti-anti-antibody and so on. Eventually, however, the level of [anti] n-antibody is not sufficient to induce another round and the cascade ends....
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REGULATION OF THE HUMORAL RESPONS1 - interactions with...

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