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Unformatted text preview: following table. Altered Receptors 1. Beta-lactams Altered Penicillin Binding Proteins 2. Macrolides Methylation of 2 adenine residues in 23S RNA of the 50S subunit 3. Rifampin Single amino acid change in RNA polymerase -subunit 4. Sulfonamide/trimethoprim Altered synthetase binds pABA preferentially/altered reductase for TMP 5. Nalidixic acid Altered gyrase 6. Streptomycin Altered S12 protein in 30S subunit Decreased Entry 1. Normally biphasic, active transport reduced 2. Fosfomysin (chromosomal) Glucose-6-phosphate transport reduced Destruction/Inactivation 1. acetyltransferase Acetylates 2. Beta-lactamase Cleaves -lactam ring 3. Aminoglycosides Acetylation or phosphorylation as drug passes membrane...
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- Fall '10