Sites of Activity - Vancomycin Inhibition of membrane...

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Sites of Activity A third means of classifying antimicrobials is by their site of activity within the target cell . Further, antimicrobials may affect either the integrity or the synthesis of these sites. The various cellular targets include the cell wall, the plasma membrane, the nucleic acids and proteins. The following table lists these sites and gives examples of antimicrobials acting against them. Site of Activity Example Antibiotics Inhibition of cell wall integrity Lysozyme Inhibition of cell wall synthesis 1. Biosynthetic enzymes (cytoplasmic) Fosfomycin, Cycloserine 2. Membrane-bound phospholipid carrier Bacitracin 3. Polymerization of subunits Beta-lactams 4. Combine with wall substrates
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Unformatted text preview: Vancomycin Inhibition of membrane integrity Surfacants, Polyenes, Polypeptides Inhibition of membrane synthesis None Inhibition of nucleic acid integrity Alkylating, Intercalating agents (mitomycin, chloroquin) Inhibition of nucleic acid synthesis 1. Metabolism of DNA 5-Fluorocytosine, , NTP analogs 2. Replication of DNA Nalidixic acid, Novobiocin, Nitroimadazoles 3. Synthesis of RNA Rifampin Protein integrity Phenolics, Heavy metals Protein synthesis 1. 30S Subunit Streptomycin, Kanamycin, 2. 50S Subunit , Macrolides (Clindamycin, Erythromycin) 3. Folate metabolism Sulfonamides, Trimethoprim c...
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