T - antigen specificity to its B-cell, the TCR allows...

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T-CELL RECEPTOR (TCR) MOLECULES The T-cell receptor molecule (TCR) is structurally and functionally similar to the B-cell immunoglobulin receptor. TCR is composed of two, disulfide-linked polypeptide chains, alpha and beta, each having separate constant and variable domains much like immunoglobulins. The variable domain contains three hypervariable regions that are responsible for antigen recognition. Genetic diversity is ensured in a manner analogous to that for immunoglobulins (click here for more information) . Thus, just like the B-cell surface immunoglobulin provides
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Unformatted text preview: antigen specificity to its B-cell, the TCR allows T-cells to recognize their particular antigenic moiety. However, T-cells cannot recognize antigen without help; the antigenic determinant must be presented by an appropriate (i.e. self) MHC molecule. Upon recognition of a specific antigen, the signal is passed to the CD3 molecule and then into the T-cell, prompting T-cell activation and the release of lymphokines. The following images illustrate the structure of the TCR as seen schematically, and three dimensionally from the side....
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This note was uploaded on 11/05/2011 for the course BIOLOGY MCB2010 taught by Professor Jessicadigirolamo during the Fall '10 term at Broward College.

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