TYPE II HYPERSENSITIVITY

TYPE II HYPERSENSITIVITY - There are many examples of Type...

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TYPE II HYPERSENSITIVITY Type II or Cytotoxic Hypersensitivity also involves antibody-mediated reactions. However, the immunoglobulin class (isotype) is generally IgG. In addition, this process involves K-cells rather than mast cells. K-cells are, of course, involved in antibody-dependent cell- mediated cytotoxicity (ADCC). Type II hypersensitivity may also involve complement that binds to cell-bound antibody. The difference here is that the antibodies are specific for (or able to cross-react with) "self" antigens. When these circulating antibodies react with a host cell surface, tissue damage may result. Click the image to animate the process
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Unformatted text preview: . There are many examples of Type II hypersensitivity. These include: • Pemphigus: IgG antibodies that react with the intracellular substance found between epidermal cells. • Autoimmune hemolytic anemia (AHA): This disease is generally inspired by a drug such as penicillin that becomes attached to the surface of red blood cells (RBC) and acts as hapten for the production of antibody which then binds the RBC surface leading to lysis of RBCs. • Goodpasture's syndrome: Generally manifested as a glomerulonephritis, IgG antibodies that react against glomerular basement membrane surfaces can lead to kidney destruction....
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TYPE II HYPERSENSITIVITY - There are many examples of Type...

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