TYPE III HYPERSENSITIVITY

TYPE III HYPERSENSITIVITY - the glomerulus leading to...

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TYPE III HYPERSENSITIVITY Type III or Immune Complex hypersensitivity involves circulating antibody that reacts with free antigen. These circulating complexes can then become deposited on tissues. Tissue deposition may lead to reaction with complement, causing tissue damage. this type of hypersensitivity develops as a result of systematic exposure to an antigen and is dependent on i) the type of antigen and antibody and ii) the size of the resulting complex (click here for more information) . More specifically, complexes that are too small remain in circulation; complexes too large are removed by the glomerulus; intermediate complexes may become lodged in
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Unformatted text preview: the glomerulus leading to kidney damage. Click the image to animate the process . One example of a Type III hypersensitivity is serum sickness , a condition that may develop when a patient is injected with a large amount of e.g. antitoxin that was produced in an animal. After about 10 days, anti-antitoxin antibodies react with the antitoxin forming immune complexes that deposit in tissues. Type III hypersensitivities can be ascertained by intradermal injection of the antigen, followed by the observance of an "Arthus" reaction (swelling and redness at site of injection) after a few hours....
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