A conceptual model for this notion of constrains is to think of there being

A conceptual model for this notion of constrains is to think of there being

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A conceptual model for this notion of constrains is to think of there being canalization of developmental programs. Waddington's model of development as a ball rolling down a landscape suggests that the program is canalized to follow a particular trough. Mutations and/or environmental fluctuations (next lecture) might knock the ball around in the trough, and if these perturbations were strong enough might throw the developmental program over into a
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Unformatted text preview: new canalized ontogeny. In this model the location of the troughs suggests that events that perturb development early on are more likely to result in major changes in the developmental plan. Perhaps developmental programs become more "canalized" as they proceed through development. This is of particular significance in light of the network of genes described above that establish body plan duringearly embryogenesis....
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