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Synthesis and release - synthesis in cell body(esp peptides...

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Synthesis and release - triggered 1. Secretory Cells a. synthesize and release chemicals b. hydrophilic chemicals - vesicle storage and release c. lipophilic chemicals - move through membranes / binding proteins 2. Gland and Cell Types a. Exocrine Glands - secretion into lumen - duct allows release to outside of body (e.g. skin / digestive tract) b. Endocrine Glands - cells in close association with capillaries - secretion into interstitial space - diffusion into blood - transport to target c. Neurosecretory Cells - neurons / endings near capillaries - release into blood - release site
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Unformatted text preview: - synthesis in cell body (esp. peptides)- axonal transport to terminals 3. Mechanism of release a. steroids: - lipid soluble - readily enter cells- stimulus leads to biosynthesis- synthesized steroid leaks out- storage in fat tissues- transport in blood assisted by carrier proteins (serum albumin) b. hormones that are NOT steroids or lipids- synthesized, packaged into vesicles via golgi - vesicles migrate to and collect at release site- activated release- exocytosis to dump contents- typically Ca++ sensitive; regulate Ca++ / regulate release...
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