BI 107DNA student - Genetics Study of hereditary...

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1/21/2011 1 DNA BI 107 Dr Potter Genetics Study of hereditary information Contained in chromosomes / genes Determines most of our traits Regulates cell’s activities Passed on to next generation Genetics Basic principles of heredity were first described in the 1860s (Gregor Mendel) Knowledge of DNA, cell cycle and chromosomes not known then DNA Before 1940s: Did not know DNA was genetic information Chromosome is 50% DNA, 50% protein DNA only has 4 monomers, protein has 20 In 1940s: Proven that DNA was the genetic info DNA D eoxyribon ucleic a cid = polymer of nucleotides Nucleotides: PO 4 deoxyribose nitrogen ring PO 4 and deoxyribose are the same in all DNA nucleotides Nitrogen ring can be one of four: adenine, cytosine, guanine, thymine Hence, only 4 monomers in all of DNA of all species DNA Nucleotide 1’ = Nitrogen ring 3’ = OH group 5’ = Phosphate Hence: 5’ end w/ PO 4 3’ end w/ OH
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1/21/2011 2 DNA Edwin Chargaff’s rules (1940s): # of A = # of T or A-T # of C = # of G or C-G DNA 1953 James Watson (American) and
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