MOL CLASS 18 - Protein Architecture (class notes S11)

MOL CLASS 18 - Protein Architecture (class notes S11) - 11...

Info iconThis preview shows pages 1–21. Sign up to view the full content.

View Full Document Right Arrow Icon
1 NATURAL SCIENCE II: MOLECULES OF LIFE Spring 2011 Class 18 – Wednesday, April 6 Protein Architecture Reading: Chapter 17 Next class: Midterm Exam 2 OUTLINE (1) (2) Structure and diversity of amino acids (3) Making a peptide bond (4) Principles of protein architecture primary, secondary, tertiary, quaternary (5) Sickle cell anemia – a molecular disease
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 ANNOUNCEMENTS
Background image of page 2
3 REVIEW
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 STRUCTURE OF AMINO ACIDS
Background image of page 4
5 AMINO ACIDS ARE CHIRAL MOLECULES
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 DIVERSITY OF AMINO ACID SIDECHAINS There are 20 TYPES OF AMINO ACID that are commonly found in proteins. Amino acids differ in the chemical structure of their SIDECHAINS (R). We can organize the 20 sidechains into four chemical groups :
Background image of page 6
7
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
8
Background image of page 8
9 MAKING A PEPTIDE BOND
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
THE PEPTIDE BOND IS PLANAR 10
Background image of page 10
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 12
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 14
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 16
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 18
Background image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 20
Background image of page 21
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 11 FOLDING THE POLYPEPTIDE CHAIN 12 PROTEIN ARCHITECTURE SECONDARY STRUCTURE (1) alpha helix 13 14 SECONDARY STRUCTURE (2) beta sheet TERTIARY STRUCTURE 15 16 QUATERNARY STRUCTURE 17 SICKLE CELL ANEMIA: a molecular disease 18 WHAT CAUSES SICKLE CELL ANEMIA? Sickle cell anemia arises from a mutation in the gene for the -chain of hemoglobin. The child must inherit the mutation from both parents to develop the disease. 19 SICKLE HEMOGLOBIN (HbS) H 2 N C C CH 2 OH O C O-O H GLUTAMIC ACID polar (hydrophilic) sidechain H 2 N C C CH OH O CH 3 CH 3 H VALINE non-polar (hydrophobic) sidechain 20 HbS FORMS INSOLUBLE FIBERS IN THE CELL 21 SUMMARY OF SICKLE CELL ANEMIA...
View Full Document

This note was uploaded on 11/05/2011 for the course MAP V55.0310.0 taught by Professor Tracejordan during the Spring '11 term at NYU.

Page1 / 21

MOL CLASS 18 - Protein Architecture (class notes S11) - 11...

This preview shows document pages 1 - 21. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online