MOL CLASS 22 - Enzymes and Drug Design (Part 1) (class notes S11)

MOL CLASS 22 - Enzymes and Drug Design (Part 1) (class notes S11)

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Class 22 – Enzymes and Drug Design (1) Molecules of Life – Spring 2011 1 NATURAL SCIENCE II: MOLECULES OF LIFE Spring 2011 Class 22 – Monday, April 25 Enzymes and Drug Design – Part 1 Reading: Chapter 20, pp. 1 – 15 Next class: Chapter 20, pp. 16 – 25 OUTLINE (1) Announcements & review (2 How does an enzyme recognize its substrate? 1 (2) (3) Enzymes and HIV replication (4) What is an enzyme inhibitor? (5) HIV protease inhibitor drugs (6) The end of AIDS? ANNOUNCEMENTS
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Class 22 – Enzymes and Drug Design (1) Molecules of Life – Spring 2011 2 REVIEW 3 “STICKASE” – A Hypothetical Enzyme 4
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Class 22 – Enzymes and Drug Design (1) Molecules of Life – Spring 2011 3 HOW DOES AN ENZYME RECOGNIZE ITS SUBSTRATE? An initial model. Enzymes bind only specific substrate molecules and ignore others – HOW? H H 3C H HO 5 COO- HO NH 3 + OH CH 3 COO- NH 3 + H 3 C OH CH 3 ENZYME ACTIVE SITE ENZYME ACTIVE SITE (a) (b) HOW DOES AN ENZYME RECOGNIZE ITS SUBSTRATE? A revised model 6
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Class 22 – Enzymes and Drug Design (1) Molecules of Life – Spring 2011
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This note was uploaded on 11/07/2011 for the course MAP V55.0310.0 taught by Professor Tracejordan during the Spring '11 term at NYU.

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MOL CLASS 22 - Enzymes and Drug Design (Part 1) (class notes S11)

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