MOL CLASS 22 - Enzymes and Drug Design (Part 1) (class notes S11)

MOL CLASS 22 - Enzymes and Drug Design (Part 1) (class notes S11)

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1 NATURAL SCIENCE II: MOLECULES OF LIFE Spring 2011 Class 22 – Monday, April 25 Enzymes and Drug Design – Part 1 Reading: Chapter 20, pp. 1 – 15 Next class: Chapter 20, pp. 16 – 25 OUTLINE (1) (2) How does an enzyme recognize its substrate? (3) Enzymes and HIV replication (4) What is an enzyme inhibitor? (5) HIV protease inhibitor drugs (6) The end of AIDS?
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ANNOUNCEMENTS
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3 REVIEW
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4 “STICKASE” – A Hypothetical Enzyme
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5 HOW DOES AN ENZYME RECOGNIZE ITS SUBSTRATE? An initial model. Enzymes bind only specific substrate molecules and ignore others – HOW? H COO- HO H 3 C NH 3 + OH CH 3 H COO- HO NH 3 + H 3 C OH CH 3 ENZYME ACTIVE SITE ENZYME ACTIVE SITE (a) (b)
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6 HOW DOES AN ENZYME RECOGNIZE ITS SUBSTRATE? A revised model
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GLUCOSE (a sugar) is the starting point for a metabolic pathway that generates energy in the form of ATP . The first step of this pathway is the addition of a PHOSPHATE GROUP to a glucose molecule. This reaction is catalyzed by an enzyme called HEXOKINASE . HEXOKINASE – an example of induced fit
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MOL CLASS 22 - Enzymes and Drug Design (Part 1) (class notes S11)

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