MOL CLASS 16 - Genetic Information (Part 1) (class notes S11)

MOL CLASS 16 - Genetic Information (Part 1) (class notes S11)

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1 NATURAL SCIENCE II: MOLECULES OF LIFE Spring 2011 Class 16 – Wednesday, March 30 Genetic Information (Part 1) Reading: Chapter 15, pp. 1 – 9 Next class: Chapter 15, pp. 9 – 13 (“bare bones”) OUTLINE (1) (2) The DNA double helix (3) DNA replication (4) The flow of genetic information (5) Transcription: DNA mRNA (6) Translation: mRNA protein
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2 ANNOUNCEMENTS
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3 REVIEW N N N N NH 2 O H O H H H CH 2 H P O O O - N NH 2 O N O H O H H H CH 2 H P O O O - O H O H H H CH 2 H P O O O - O H OH H H H CH 2 H NH N N N O NH 2 NH N O O H 3 C 5' 3' 5' 5' 5' 3' 3' 3' ADENINE CYTOSINE GUANINE THYMINE phosphodiester linkage 5'-end 3'-end OH P O OH O
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4 DNA BASE PAIRING THYMINE ADENINE CYTOSINE GUANINE pyrimidine purine
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5 THE DNA DOUBLE HELIX
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6 PARAGRAPH 12
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7 FROM DNA TO PROTEINS How does a cell “read” the genetic information in DNA and use it to make molecules with a biological function ?
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8 COMPARING DNA & RNA
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9 TRANSCRIPTION (DNA mRNA)
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10
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Unformatted text preview: THE GENETIC CODE 11 THE LANGUAGE OF PROTEINS amino acids C H C R N O O H H H carboxylic acid amine sidechain alpha-carbon 12 THE CHALLENGES OF TRANSLATION 13 CRACKING THE CODE What is the code for translating specific mRNA bases into specific amino acids? Question 1: How many mRNA bases are in one codon? 1 mRNA base 4 possibilities 2 mRNA bases 4 x 4 = 16 possibilities 3 mRNA bases 4 x 4 x 4 = 64 possibilities Question 2: Which codons produce which amino acids? U U U U U U . Phe Phe Phe Phe . A A A A A A Lys Lys Lys Lys . . A U A U A U Ile Tyr Ile Tyr Ile - 14 THE GENETIC CODE TABLE...
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MOL CLASS 16 - Genetic Information (Part 1) (class notes S11)

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