MOL CLASS 15 - DNA (Part 3) (class notes S11)

MOL CLASS 15 - DNA (Part 3) (class notes S11) - • What is...

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1 NATURAL SCIENCE II: MOLECULES OF LIFE Spring 2011 Class 15 – Monday, March 28 DNA – The Molecule of Heredity (Part 3) Reading: Chapter 14, pp. 16 – 25 (skip section 14.5) Next class: Chapter 15, pp. 1 – 9 (“bare bones”) OUTLINE (1) (2) The DNA bases (3) Making a polynucleotide strand (4) (5) Structure of the DNA double helix (6) DNA replication
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2 ANNOUNCEMENTS
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3 NUCLEOTIDES – BUILDING BLOCKS OF DNA deoxyribose
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4 MAKING A NUCLEOTIDE (1): Adding the Phosphate
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5 DNA CONTAINS 4 (NITROGENOUS) BASES N C N C C C N H 2 O H H H cytosine N C N C C C O H H 3 C H thymine H O pyrimidine DNA bases C C N C N C H H H H pyrimidine * * N C N C C C N C N H H H 2 N O guanine N C N C C C N C N H H H N H 2 adenine p u r i n e D N A b a s e s N C N C C C N C N H H H H purine * *
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6 MAKING A NUCLEOTIDE (2): Adding the Base
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7 A POLYNUCLEOTIDE STRAND N N N N NH 2 O H O H H H CH 2 H P O O O - N NH 2 O N O H O H H H CH 2 H P O O O - O H O H H H CH 2 H P O O O - O H OH H H H CH 2 H NH N N N O NH 2 NH N O O H 3 C 5' 3' 5' 5' 5' 3' 3' 3' ADENINE CYTOSINE GUANINE THYMINE phosphodiester linkage 5'-end 3'-end OH P O OH O
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WHAT IS THE STRUCTURE OF DNA? How many polynucleotide strands does DNA contain – one? two? three? more?
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Unformatted text preview: • What is the structure of the polynucleotide strand(s). Do they form a helix? Or some other shape? • Where are the bases…on the inside or the outside? • Does the molecular structure of DNA explain how DNA makes copies of itself? – i.e., relate structure to function . 8 Francis Crick &James Watson Rosalind Franklin Maurice Wilkins Linus Pauling 9 http://www.pbs.org/wgbh/nova/photo51 DISCOVERING THE DNA DOUBLE HELIX 10 PHOTO 51 11 12 PARAGRAPH 4 13 14 THE TWO DNA STRANDS ARE ANTIPARALLEL A C T A G C T A T G A T C G A T 5'-end 3'-end 3'-end 5'-end (a) (b) 15 PARAGRAPHS 7, 8 & 9 16 DNA BASE PAIRING THYMINE – ADENINE CYTOSINE – GUANINE pyrimidine purine 17 THE DNA DOUBLE HELIX A-T base pair 18 PARAGRAPH 12 19 ANIMATION OF DNA REPLICATION THE MESELSON – STAHL EXPERIMENT (1958) 20...
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This note was uploaded on 11/07/2011 for the course MAP V55.0310.0 taught by Professor Tracejordan during the Spring '11 term at NYU.

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MOL CLASS 15 - DNA (Part 3) (class notes S11) - • What is...

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