STUDY GUIDE - Midterm 1 (MOL S11) (1)

STUDY GUIDE- - V55.0310 NATURAL SCIENCE II THE MOLECULES OF LIFE SPRING 2011 STUDY GUIDE FOR MIDTERM EXAM 1 These questions should be used to guide

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V55.0310 NATURAL SCIENCE II: THE MOLECULES OF LIFE SPRING 2011 STUDY GUIDE FOR MIDTERM EXAM 1 These questions should be used to guide your studying for the midterm exam. The study questions are the same as the ones posted each week, but they have been re-organized to correspond to the textbook chapters This will help you to align your class notes and chapter readings. Some questions address foundational knowledge and concepts, with important scientific terms highlighted in bold . Other questions ( written in italics ) identify certain skills that you should develop throughout the course. Development of Aspirin Since the time of Hippocrates, what natural source has been used as a potion to treat pain and fever? In the 19 th century, what substance was identified as the active ingredient in these potions? What is the objective of chemical synthesis ? How did Felix Hoffman modify salicylic acid to create the substance we now call Aspirin ? Aspirin was originally sold as a powder but later it was sold as tablets . Why was this change made? How does Aspirin Work? What is meant by the oral bioavailability of a drug? Why is this important for a medicine’s effectiveness? In general, what is the biological role of enzymes ? 1
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What is the name of the specific enzyme that serves as the target for Aspirin ? What is the function of this enzyme in the human body? Explain how Aspirin reduces pain by functioning as an enzyme inhibitor . Can Aspirin Be Improved? Describe the different roles of COX-1 and COX-2 enzymes in the human body. Explain why Aspirin is called a non-selective inhibitor whereas Vioxx is called a selective inhibitor ? What difference in structure between the COX-1 and COX-2 enzymes permits Vioxx to act as a selective inhibitor of COX-2? Why does this difference not affect Aspirin’s ability to inhibit both enzymes? LAB 1: WHAT HAPPENED WITH VIOXX? We were not able to have this lab session because of a snow day, but you should be familiar with the New York Times reading on why Vioxx was recalled. 2
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CHAPTER 2: THE ATOMIC ALPHABET The Atomic Alphabet Write a short explanation for how letters and words can be used as an analogy for atoms and molecules . Illustrate your explanation with some examples. The Chemical Elements Define the following chemical terms – mixture , compound , element . Provide one example of each. Describe some key principles about
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This note was uploaded on 11/07/2011 for the course MAP V55.0310.0 taught by Professor Tracejordan during the Spring '11 term at NYU.

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STUDY GUIDE- - V55.0310 NATURAL SCIENCE II THE MOLECULES OF LIFE SPRING 2011 STUDY GUIDE FOR MIDTERM EXAM 1 These questions should be used to guide

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