CellCycleSlides - The Cell Cycle: Regulation and Division...

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The Cell Cycle: Regulation and Division CSC 858 3/17/05 Dr. Andrew Bieberich Dr. Michael Goldman Reading: Tozeren and Byers Chapter 7 For April 7, read Chapter 3 Copyright Andrew Bieberich 2005
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Ultimately, cells decide whether to divide or not based upon input of information from outside the cell. single cells (yeast, bacteria) Are there enough nutrients? Are toxic waste molecules too concentrated to proceed without cell damage? cells within multi-cell organisms Is the cell attached to others? Is it too crowded? Are the correct growth factors present?
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Regulation of the multi-celled eukaryotic cell cycle 1. Semi-modular control system. 2. Five major checkpoints that act as switches in the system. 3. Cyclin and Cyclin and Cyclin. .. 4. Growth factors coordinate cell cycles across multiple cells. 5. G 0 , when time stands still. 6. Cancer: when switches malfunction. G1 START M S DNA replication checkpoint DNA damage checkpoint G2 metaphase checkpoint degredation of metaphase cyclins
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Across cell types, the cell cycle may take minutes, months, or arrest indefinitely. Therefore, we know that something sophisticated must be controlling it. A “clock” is not flexible. Phase triggering is only slightly more so. The system required is one that uses switches controlled by subsystems with feedback. G1 START M S DNA replication checkpoint DNA damage checkpoint G2 metaphase checkpoint degredation of metaphase cyclins
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G1 Chromosomes become uncondensed. Also called ‘G0’ if cell arrests in this state. START
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This note was uploaded on 11/07/2011 for the course BYS 201 taught by Professor Podila during the Spring '09 term at University of Alabama - Huntsville.

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CellCycleSlides - The Cell Cycle: Regulation and Division...

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