Ch01.2-12Sept%20%28revised%29

Ch01.2-12Sept%20%28revised%29 - Chapter 1 Review of the...

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Unformatted text preview: Chapter 1 - Review of the Immune System MBB/HSCI 426: Immune System I Chapter 1; pp. 1-36, continued Friday 9 September 2011 Exam 1 is first thing on Monday 12 September The Molecular Basis of Adaptive Immunity Antigen-specific Receptors on B cells and T cells B cells: B cell receptor (attached to surface) Antibodies (same molecule, but secreted by the B cell) T cells: T cell receptor (attached to cell surface) TcRs are never secreted T-cells recognize peptide fragments from proteins that are taken into the cell, either by intracellular infection, or by endocytosis MHC I and II have different structures and functions There are two general types of T cell, with each recognizing peptide bound to a different class of MHC molecule (I or II) T cells bearing the CD8 molecule bind to Class I MHC molecules. MHC I molecules are on all cells Cytotoxic T cells (Tc) kill cells bearing complexes of peptides from foreign antigens bound to their MHC I molecules. T cells bearing the CD4 molecule bind to Class II MHC molecules . MHC II molecules are on antigen-presenting cells (APCs) APCs are macrophages (MQ), dendritic cells (DCs) or B cells CD4 T cells are regulatory, and there are several types of them T cells that activate macrophages ( TH1 T cells ) T cells that activate B cells ( TH2 or helper T cells ) [Treg cells suppress immune responses] [TH17 cells secrete cytokines supporting inflammatory responses] Class I MHC is on the surface of almost all cell types Class II MHC is located on the surface of “antigen presenting cells”: Dendritic cells (DCs), macrophages (MQs) and B cells. The Life of a Lymphocyte in a Lymphocyte Repertoire • Naïve repertoires of B and T cells are generated in the bone marrow and thymus, respectively, through recombination of gene segments. • Mature naïve cells migrate to the secondary lymphoid tissues, where T cells sample “activated” APCs for antigen in T-cell rich (parafollicular) areas, and where B cells sample follicular dendritic cells (FDCs) for antigen in B-cell rich (follicular) areas....
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This note was uploaded on 11/05/2011 for the course MBB 426 taught by Professor Scott during the Spring '11 term at Simon Fraser.

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Ch01.2-12Sept%20%28revised%29 - Chapter 1 Review of the...

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