Ch02.1-12Sept

Ch02.1-12Sept - Chapter 2, Part I - Innate Immunity MBB...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Chapter 2, Part I - Innate Immunity MBB 426/726, HSCI 426; Immune System I Chapter 2 (pp. 37-71) Monday 12 September 2011 Wednesday 14 September 2011 Friday 16 September 2011 MEDIATORS OF THE THREE PHASES OF IMMUNITY Immediate: Natural antibodies (B1 B cells, immune complex formation, C activation), Complement Antimicrobial peptides, mucus, surfactant Alpha- and beta-interferons (IFN- , IFN- ) Resident macrophages (vasoactive lipid mediators, phagocytosis, cytokines later) Mast cells (antigen on IgE, complement fragments C5a, C3a) /-T cells (??) Intermediate: Macrophage (entry and) activation Neutrophil entry and activation NK cells/NK-Tcells Acute-phase reactants T-cell-independent extrafollicular antibody responses (marginal zone B cells) Dendritic cell activation (-> 2 o LT to activate T-cells & B2 B cells) Adaptive: Effector/activated cytotoxic T cells (entry and direct cell killing) Memory/activated TH1 cells (entry and macrophage activation) T-cell-dependent antibody responses (B2 B cells) Pathogens exist at different sites in the body/cell...
View Full Document

Page1 / 34

Ch02.1-12Sept - Chapter 2, Part I - Innate Immunity MBB...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online