Ch02.1-14Sept

Ch02.1-14Sept - Chapter 2, Innate Immunity: First Lines of...

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Unformatted text preview: Chapter 2, Innate Immunity: First Lines of Defense MBB 426/726, HSCI 426; Immune System I Chapter 2 (pp. 37-71) Monday 12 September 2011 Wednesday 14 September 2011 Friday 16 September 2011 Chapter 2, Complement Wednesday 14 September Complement An enzyme-activating cascade leading to: Production of soluble mediators of inflammation (anaphylotoxins): C5a >> C3a >> (C4a) Opsonization of pathogens (enhancing phagocytosis): C3b >> C4b Pore formation and lysis of membranes (bacteria, enveloped viruses, cells): C5-C9 Several paths leading to initiation of the complement cascade Innate: mannose binding lectin, ficolins, natural antibody, intrinsic activation Adaptive: antibodies induced by specific antigen (IgM >> IgG) Three general pathways: Mannose binding lectin (MBL), ficolins (replace C1q in classical pathway) Classical pathway (Ab-mediated by single IgM>poly IgG; C-reactive protein) Alternative pathway (intrinsic activation and amplification loop) Simplified Overview of the Complement Pathways The complement system is very old, dating back well before vertebrates. The lectin pathway is initiated by the innate molecules, MBL and ficolin...
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Ch02.1-14Sept - Chapter 2, Innate Immunity: First Lines of...

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