Ch02.1-16Sept

Ch02.1-16Sept - Chapter 2 Part I Innate Immunity MBB...

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Chapter 2, Part I - Innate Immunity MBB 426/726, HSCI 426; Immune System I Chapter 2 (pp. 37-71) Monday 12 September 2011 Wednesday 14 September 2011 Friday 16 September 2011
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Chapter 2, Complement Wednesday 14 September
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Figure 9-28
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The classical pathway is initiated by C1qrs and antibody, to form C4b2a, which cleaves C3 to C3b that covalently attaches to surfaces via its reactive thiol group, and soluble C3a, a weak anaphylotoxin.
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Alternative pathway: The C3 convertase “amplification loop”
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Alternative pathway: Spontaneous initiation by hydrolyzed C3 (C3(H 2 O))
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C3bBbP is the main C3 convertase; but C4b2a is also a C3 convertase; both complexes cleave C3 to C3a + C3b.
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Effector Functions and Regulation of Complement Friday, 16 September
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Soluble : P, I, H, C1INH, C4BP Cell surface : CR1, MCP, DAF, CD59
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Anaphylotoxins C5a >> C3a >> C4a in potency
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C3b is further cleaved to form C3dg and C3d, recognized by CR2 on B cells and follicular dendritic cells C3b is cleaved to form iC3b, which is recognized by
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Ch02.1-16Sept - Chapter 2 Part I Innate Immunity MBB...

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