Ch05.1-03Oct

Ch05.1-03Oct - Figure 1-8 part 2 of 2 Somatic hypermutation...

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Chapter 4: The Generation of Lymphocyte Antigen Receptors MBB/HSCI 426, MBB 726 Immune System I Monday & Wednesday 3 & 5 October 2011 This lecture was taken from: Chapter 5, pp. 157-197
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Chapter 4: The Generation of B-Lymphocyte Antigen Receptors MBB/HSCI 426, MBB 726 Immune System I Monday 3 October 2011 This lecture was taken from: Chapter 5, pp. 157-169
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Figure 3-6
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Figure 3-7
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Germline organization of human Ig heavy and light chain genes.
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Covalently closed ends must be nicked for joining Open, blunt ends are easy to ligate directly DNA is nicking site is imprecise TdT extends DNA ends, exonuclease chews back ends Final result: imprecise end joining
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Chapter 4: (Structural Variation in Ig Constant Regions) and Secondary Diversification of the Antibody Repertoire MBB/HSCI 426, MBB 726 Immune System I Monday 3 October 2011 This lecture was taken from: Chapter 4, pp. (173-179), and 179-186
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Unformatted text preview: Figure 1-8 part 2 of 2 Somatic hypermutation Affinity Maturation Heavy-chain class switching Occur in B cells (but not T cells) And are all T-cell driven processes They occur mostly in the germinal centers of the secondary lymphoid tissues (described in Ch 7). All 3 processes occur after antigen stimulation and are mediated by the enzyme, AID Pu -> Pu and Py -> Py Pu -> Py and Py -> Pu Creating Antibody Repertoires in Vitro Synthetic libraries (phage, yeast display) Immune libraries Nave libraries Transgenic mice producing human Abs Humanized mice Evolution of the Adaptive Immune Response MBB/HSCI 426, MBB 726 Immune System I Monday 3 October 2011 This lecture was taken from: Chapter 5, pp. 187-196 Chickens diversify the antibody genes of their primary B cell repertoires through gene conversions mediated by AID. People do so only rarely....
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Ch05.1-03Oct - Figure 1-8 part 2 of 2 Somatic hypermutation...

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