Ch06.2-12%2614Oct

Ch06.2-12%2614Oct - Ch. 6: Genetics of the MHC Locus and...

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Ch. 6: Genetics of the MHC Locus and Functions of the MHC Molecules MBB/HSCI 426, MBB 726; Immune System I Friday 14 October 2011 This lecture is taken from: Ch 6: pp. 217-233
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HAPLOTYPE = the alleles on a given chromosome (i.e., LINKED alleles) Mouse MHC nomenclature: K b (K molecule of the b haplotype) I-A d (I-A molecule of the d haplotype) Studies using SYNGENEIC (= identical genotype) mice ALLOGENEIC (= “allelic” genotype) mice are a different strain from a reference mouse. In immunological studies, they are typically inbred mice that have a different MHC haplotype from the reference strain under study. XENOGENEIC = (= “foreign” genotype) different species. CONGENIC means there is a single gene or region that is allelic between two mice. Typically it refers to class I or II MHC genes. Mice of haplotype 1 are crossed on those with haplotype 2, then repeatedly back-crossed on haplotype 1, but using mice that have retained a specified haplotype-2 MHC molecule. After 20-30 generations of backcrossing,
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This note was uploaded on 11/05/2011 for the course MBB 426 taught by Professor Scott during the Spring '11 term at Simon Fraser.

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Ch06.2-12%2614Oct - Ch. 6: Genetics of the MHC Locus and...

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