Ch07.2-20Oct

Ch07.2-20Oct - Ch. 7: Signaling through Immune System...

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Ch. 7: Signaling through Immune System Receptors MBB/HSCI 426, MBB726 Immune System I Chapter 7: pp. 239-271 Exam 4: Friday 21 October
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This part of Wednesday’s lecture is taken from: Ch 7: pp. 258-264
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Figure 8-30
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Summary Table for B-cell and T-cell Signaling B cell T cell Antigen Receptor (initiates Signal 1) 1 IgM, D, A, E or G 1 alpha/beta TcR also in Agn Receptor complex [CD19/CD81/CD21(CR1,2) complex] more like CD28 CD4/8 Src-family receptor-associated Tyr kinase(s) and inhibitor Blk, Fyn, Lyn Lck (CD4/8), Fyn (TcR), CD45 Ser/Thr Kinase Syk (binds PO 4 -Ig β 29 Zap-70 (binds PO 4 - ζ ) BLNK Shc/Grb2 LAT/GADS/SLP-76 Guanine-nucleotide exchange factor RasGRP Ras GRP Small G protein Ras Ras 3 MAP kinases Raf, Mek, Erk (Transc F Elk1) Raf, Mek, Erk (Transc F Elk1) Transcription factor made from two halves Fos (JNK kinase -> Jun) = AP-1 Fos (JNK kinase -> Jun)=AP-1
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Ch07.2-20Oct - Ch. 7: Signaling through Immune System...

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