Ch030.2-21Sept

Ch030.2-21Sept - Chapter 3: The Induced Responses of Innate...

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Chapter 3: The Induced Responses of Innate Immunity Chapter 3; pp. 75-121 Lecture 1: Monday 19 September 2011 Lecture 2: Wednesday 21 September (old Exam-2 handout) Weekly Tutorial: Using PubMed and Web of Science Exam 2: Friday 23 September (Chapters 2 & 3)
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Chapter 3 (continued): The Induced Responses of Innate Immunity Chapter 3; pp. 75-121 Lecture 2: Wednesday 21 September (old Exam-2 handout) Exam 2: Friday 23 September (Chapters 2 & 3)
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Neutrophils Migration from the circulation into tissues - Endothelial activation & up-regulation of adhesion molecules - Rolling adhesion (selectin-CHO interaction) - Stopping (integrin-ICAM interaction; - CR3/Mac-1+ICAM-1/iC3b - LFA-1+ICAM-1&2) - Chemokine causes high affinity interactions - 3 kinds of granules by microscopic staining: 1o (lysosome), 2o, 3o Monocytes/Macrophages Migration from the circulation into tissues - Endothelial activation & up-regulation of adhesion molecules - Rolling adhesion (selectin-sialyl Lewis x interaction) - Stopping via integrin-ICAM interactions (enhanced by chemokine) - CR3/Mac-1+ICAM-1/iC3b - LFA-1+ICAM-1&2 - Chemotaxis into tissues (chemokine CCL2) Lysosomes (simpler than neutrophil)
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Neutrophil entrance into the tissues from the circulation. As local stasis develops (slowing of the movement of blood though local capillaries), neutrophils begin to
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Ch030.2-21Sept - Chapter 3: The Induced Responses of Innate...

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