lecture_5 - Endocrine systems Peptide hormones Steroid...

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Unformatted text preview: Endocrine systems Peptide hormones Steroid hormones Amines Hypothalamus/ pituitary gland Hormone axes Types of cell signaling Fig. 4.1/ 3.1 Direct cell signaling via gap junctions Autocrine/paracrine signaling Endocrine signaling Neural signaling Endocrine signaling Hormones Peptides Steroids Amines Peptide hormones Often synthesized as large, inactive polypeptides called preprohormones Released into circulation and eventually degraded by proteolytic enzymes (hormones have half-life) Fig. 4.23/ 3.4 Peptide hormones Often synthesized as large, inactive polypeptides called preprohormones Released into circulation and eventually degraded by proteolytic enzymes (hormones have half-life) Some hormones are activated while in circulation, e.g., angiotensinogen activated by renin Involved in negative feedback loop to control blood pressure Peptide hormones Hydrophilic, so cant cross plasma membrane Bind to cell-surface receptors Fig. 4.10/ 3.16 Hormones Peptides Steroids Amines Steroid hormones Derived from cholesterol Fig. 4.25/ 3.7 Steroid hormones Derived from cholesterol 3 major classes of steroid hormones in vertebrates (based on function): Mineralo corticoid secreted by adrenal cortex regulate fluid and electrolyte balance e.g., aldosterone Steroid hormones Derived from cholesterol 3 major classes of steroid hormones in vertebrates (based on function): Mineralo corticoid secreted by adrenal...
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lecture_5 - Endocrine systems Peptide hormones Steroid...

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