lecture_6 - • Equilibrium potential depends on...

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Membrane potential Photo from Dr. Michael Silverman’s website http://www.sfu.ca/biology/faculty/silverman/index.html
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Neural signaling Electrical signal is sent through changes in membrane potential (electrochemical gradient) Fig. 4.1/
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Membrane potential Na + /K + -ATPase (“sodium pump”) contributes to membrane potential Resting membrane potential is negative Opening sodium channels causes depolarization (less negative) Opening potassium channels causes hyperpolarization (more negative) See Fig. 3.29/ 2.51 for illustration
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Nernst equation Equilibrium potential = Where R = universal gas constant T is the temperature in Kelvin F is the Faraday constant z is the valence [X] is the concentration of ion X Equilibrium potential is less for divalent ions
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Unformatted text preview: • Equilibrium potential depends on concentration gradient ) X]inside [ X]outside [ ln( zF RT Goldman equation Membrane potential = • Na + , K + and Cl-are the major contributors to membrane potential • Permeability of membrane to ions is not fixed • Changes in permeability cause changes in membrane potential • E.g., sodium and depolarization, potassium and hyperpolarization ) ]out Cl [ ]in Na [ ]in K [ ]in Cl [ ]out Na [ ]out K [ ln( Cl Na K Cl Na K-+ +-+ + + + + + P P P P P P F RT Goldman equation Membrane potential = See http://www.nernstgoldman.physiology.arizona.edu/ ) ]out Cl [ ]in Na [ ]in K [ ]in Cl [ ]out Na [ ]out K [ ln( Cl Na K Cl Na K-+ +-+ + + + + + P P P P P P F RT...
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lecture_6 - • Equilibrium potential depends on...

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