lecture_22 - Muscles Isoforms of muscle proteins Muscle...

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Muscles Isoforms of muscle proteins Muscle types
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Transmission of signal from sarcolemma to sarcoplasmic reticulum Skeletal muscle – depolarization-induced Ca 2+ release (Fig. 6.33/ 5.30) Cardiac muscle – Ca 2+ - induced Ca 2+ release (Fig. 6.32/ 5.29) Fig. 6.31/ 5.28
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Vertebrate vs. invertebrate muscle Contraction is all or nothing within a myofiber of vertebrate neurogenic muscle Invertebrate muscles contract in response to graded excitatory potentials Flight muscles in many insects are able to contract at high frequencies Asynchronous flight muscle
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Excitation contraction coupling At rest Intracellular [Ca 2+ ] kept low by Ca 2+ - ATPases, Na + /Ca 2+ exchanger During contraction Depolarization opens Ca 2+ channels (DHPR, RyR) and reverses Na + /Ca 2+ exchanger Rise in intracellular [Ca 2+ ] Ca 2+ causes troponin and tropomyosin to move, allowing myosin to bind to actin
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Isoforms of muscle proteins Different isoforms of: Muscle myosin (Myosin II) DHPR Troponin/tropomyosin Can be used to alter properties of muscles within an individual
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This note was uploaded on 11/05/2011 for the course BISC 305 taught by Professor Christians during the Fall '11 term at Simon Fraser.

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lecture_22 - Muscles Isoforms of muscle proteins Muscle...

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