Chapter 6

Chapter 6 - 6. presence of BPG allows Hb to unload ~40% of...

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6. presence of BPG allows Hb to “unload” ~40% of its bound Hb 7. At high altitudes the body produces more BPG A single mutation in hemoglobin can lead to altered structure and function. This experiment was done a long time ago by Linus Paulding Normal Hb is called HbA (β Glu 6) – glutamic acid in the 6 th position The mutant form is called HbS (β Glu 6 Val) – this leads to sickle cell amenia o Val is a nonpolar amino acid Red blood cells are usually biconcave disks, but sickled red blood cell are caused because of mutated sickle cell anemia In the deoxy state the Val interacts with the Leu in the hydrophobic pocket Chapters 6 and 7: ENZYME CATALYSIS I. General properties of enzymes Enzymes: Catalysts in biological systems that increase the rate of reactions, but are not changed at the end of the process. Enzymes are the most efficient catalysts known Most biochemical reactions would take longer than human or cellular life if they were allowed to proceed at their own rate. In biological systems, most enzymes are proteins With the exception of some RNA (riboenzymes) Enzymes allow for: 1. Increased reaction rates specifically enzymes can increase the rate of the reaction by 10
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Chapter 6 - 6. presence of BPG allows Hb to unload ~40% of...

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