Problem_set_3

Problem_set_3 - 1 and 8 markers? 3 and 5 markers? 3 and 6...

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Problem set #3 – For Recitation the week of March 17 th . From Griffiths et al textbook: From Chapter 10 : 1, 2, 3, 4, 5 , 14 Additional Questions: A) Eight genes called 1 to 8 are present in a linear fashion (i.e. 1-2-3-4-5-6-7-8) on chromosome 2 of Arabidopsis. Strain A is homozygous for recessive mutation for all eight alleles as well as homozygous for an inversion whose breakpoints (exactly in the middle of each interval) occurred between the 2-3 genes and the 5-6 genes. Each of these genes is 5 map units apart from its neighbor. You cross the A strain to a strain containing the same inversion but otherwise WT at all eight loci. Draw out how the homologous chromosomes would pair during meiosis in the F1 heterozygote. What would the observed map distance between:
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Unformatted text preview: 1 and 8 markers? 3 and 5 markers? 3 and 6 markers? You cross an all wild-type strain (NO inversion) to strain A. Draw out how the homologous chromosomes would pair during meiosis in the F1 heterozygote. What would the observed map distance between: 1 and 8 markers? 3 and 5 markers? 3 and 6 markers? B) What is a merozygote and how is it used to analyze the control mechanisms of an operon? C) What is meant by cis and trans when these terms are used to describe regulatory mechanisms within an operon. Give an example of a mutation that is cis-dominant and one that has dominant effects both cis and trans . D) What would be the effect of a frameshift mutation near the N-terminus of the lac repressor protein in E. coli ....
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