Problem Set 7 - Proteins

Problem Set 7 - Proteins - Cyclin activate CDPK and keep...

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Problem set 7 Due the Week of April 19 th 1) Describe three mechanisms used to control the activities of the proteins that regulate the cell cycle and the cell death pathways. 1. Protein-protein interactions 2. Phosphorylation/ dephosphorylation 3. Proteolysis Protein-protein example -Retinal Blastoma Protein interacting with E2F, which is a transcription factor promoting cell cycle progression -CDPK puts phosphate on RB protein which releases E2F -CDPK and Cyclin, Cyclin binds to CDPK which allows cell cycle progression -when DNA damage, p53 activates p21 interacts with CDPK/cyclin which stops progression Phosphorylation -CDPK and cyclin can phosphorylate and dephsophorylate Proteolysis – degradation 2) What is the role of cyclins in the cell cycle? How is the level of cyclins regulated?
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Unformatted text preview: Cyclin activate CDPK and keep cell cycle progressing. Cyclins are regulated via proteolysis and gene expression (transcriptional activation). 3) What are two examples of translocations that lead to cancer, and how do they promote cell proliferation?-burkets lymphoma translocation causes cmyc to be really highly expressed which is a transcription factor involved in cell cycle progression which is constitually activated. No longer regulated. 4) How is apoptosis different from necrosis? b) Describe three characteristics of an apoptotic cell. c) Describe briefly the four phases of the cell cycle G1, S, M, G2...
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