This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: I. Dr. ALBERT HARRIS mentions Weakened Force of Traction in CANCER CELLS a. PHORBOL ESTER TUMOR PROMOTER which reduces WRINKLING OF RUBBER SUBSTRATA thereby inhibiting SMOOTH MUSCLE CONTRACTION through activation of Sodium-Potassium ATP-ase (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1917384/) a.i. You can use Dibutyryl cyclic AMP to treat CANCER CELLS a.ii. Cause CANCER CELLS to increase the FORCE OF THEIR TRACTION a.iii. And therefore CANCER CELLS develop more ACTOMYOSIN STRESS FIBERS b. In a PAPER BY S. MUVERVA called Traction Force Microscopy of MIGRATING NORMAL FIBROBLAST and H-RAS TRANSFORMED 3T3 Fibroblasts b.i. It was found that MECHANICAL INTERACTION b/w CELL/ AND SUBSTRATE are involved in vital cellular functions such as MIGRATION and SIGNAL TRANSDUCTION b.ii. Use TRACTION FORCE MICROSCOPY Visualize dynamic Characteristics of MECHANICAL FORCES by FIBROBLAST TEST Magnitude, Direction, and Shear of FIBROBLAST b.iii. they analyzed MIGRATING NORMAL and H-Ras TRANSFORMED 3t3...
View Full Document
- Fall '10
- cell biology