Stopak Paper Notes

Stopak Paper Notes - Summary Vimentin intermediate filament...

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Summary Vimentin intermediate filament network present in most mesenchymally derived cells is in part responsible for the strength and integryity of cells and necessary for tissue movement that require the generation of significant tractional forces Mice deficient for vimentin are able to undergo embryonic development absolutely normally and go onto develop into adult hood w/out any change in phenotype Fibroblasts from these mice are weak and disabled in ability to migrate and contract a 3-D collagen network Wounds in Vim-deficient show delayed migration of fibroblast to wound site and fail to heal during 24 hr culture period Background/Intro Mesenchyme , or mesenchymal connective tissue, is an example of reticular connective tissue , a type of loose connective tissue , which is derived from all three germ layers and located within the embryo . [1] Mesenchyme is characterized morphologically by a prominent ground substance matrix containing a loose aggregate of reticular fibrils and unspecialized cells . [2] The cells are capable of developing into connective tissue , bone , cartilage , the lymphatic system , and the circulatory system . [3]
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Stopak Paper Notes - Summary Vimentin intermediate filament...

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