NMR_intro_2010

NMR_intro_2010 - BCMB / CHEM 8190 Biomolecular NMR GRADUATE...

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BCMB / CHEM 8190 Biomolecular NMR GRADUATE COURSE OFFERING IN NUCLEAR MAGNETIC RESONANCE "Biomolecular Nuclear Magnetic Resonance" is a course intended for all graduate students with an interest in applications of nuclear magnetic resonance (NMR) to problems in structural and functional biology. It will begin with a treatment of the fundamentals that underlie magnetic resonance phenomena and develop this into a basis for experimental design, interpretation of data, and critical reading of the literature. http://tesla.ccrc.uga.edu/courses/bionmr/
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Syllabus I. Introduction A. M 1/11 Prestegard Magnetic properties of nuclei and electrons – precession 5-32 L B. W 1/13 Prestegard RF pulses and spin relaxation - Bloch equations 32-46 L, 626-627 L II. Instrumentation A. M 1/18 MLK Jr. Holiday (no class) B. W 1/20 Prestegard Instrumental considerations - a look at probes 89-122 L C. M 1/25 Prestegard Fourier transform methods and data Processing 72-87 L * Friday Labs are scheduled separately – intro to computer systems 1/08, 1/15
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• Biomolecular NMR - short history ~ 1985 first protein structure • Compared to X-ray ~ 1953 first protein structure • Today ~ 13 % of structures in the PDB come via NMR – higher for nucleic acids • Unique applications – weak associations, membrane associations, in-cell observation • New challenges need new methods – NMR is still an evolving science
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NMR_intro_2010 - BCMB / CHEM 8190 Biomolecular NMR GRADUATE...

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