Exam3 - Molecular Genetics Exam 3, Thursday, Nov. 18 page 1...

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Molecular Genetics Exam 3, Thursday, Nov. 18 page 1 of 6 Name _________________________________________________________________ (3 points each) In each of the following questions there are two or more statements. One is true (generally, it is taken directly from your text or another source). The other(s) have been modified so as to be untrue or misleading. Circle or otherwise designate the correct statement. 1. A region of DNA unwound by RNA polymerase is called the transcription bubble. a) Within the transcription bubble, the nascent RNA chain remains base paired with the DNA template, forming a DNA-RNA hybrid. b) Within the transcription bubble, the nascent RNA chain is immediately released from the DNA, displaced by the DNA duplex. 2. When geneticists refer to the sequence of a gene, they usually mean a) the sequence of the RNA-like strand. b) the sequence of the template strand. 3. How do cells make a mature RNA from a gene whose mature mRNA sequence is interrupted by introns? The cells a) carry out discontinuous transcription whereby the RNA polymerase skips introns, transcribing only exons. b) make a primary transcript containing both introns and exon and then remove introns by RNA splicing. 4. a) A strategy of splicing carried out by some eukaryotes, trans-splicing, joins the exon of one gene with the exon of another gene. b) All RNA splicing is cis-splicing, whereby exons of the same primary transcript are joined together. 5. The effective concentration of transcription factor (as sensed by RNA polymerase at a promoter) is greatest when it is bound: a ) About 2,000 nucleotides from the promoter. b ) About 500 nucleotides from the promoter. c ) About 200 nucleotides from the promoter. 6. Exposed regions of DNA recognized by their hypersensitivity to DNase digestion a) are associated with inactive genes. b) are associated with active genes. 7) In the case of genomic imprinting a) the expression of a gene depends on stochastic fluctuations b) the copy of a gene inherited by one parent but not the other is transcriptionally inactive.
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Molecular Genetics Exam 3, Thursday, Nov. 18 page 2 of 6 Name _________________________________________________________________
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This note was uploaded on 11/07/2011 for the course BIO 325 taught by Professor Saxena during the Summer '08 term at University of Texas at Austin.

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Exam3 - Molecular Genetics Exam 3, Thursday, Nov. 18 page 1...

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