Exam3-answers - Molecular Genetics Exam 3 Tuesday Nov 22...

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Molecular Genetics Exam 3, Tuesday, Nov. 22, 2005 page 1 of 5 --------------------------------------------------------------------------------- Your name: _____________________________________________________________ ------------------------------------------------------------------------------------------------------------- Define the following terms (5 points each): RISC RNA-induced silencing complex. Complex of proteins that bind to siRNA or miRNA, unwind it, and inhibit transcription and/or translation of RNA that is complimentary to the bound miRNA or siRNA. U1 snRNP A small nuclear ribonuleoprotein containing U1 snRNA. It is involved in splicing / splice site recognition. U1 snRNP binds to the 5’ end of the intron and forms part of the spliceosome. Haploinsufficiency A form of dominance in which the heterozygote does not produce enough protein for a normal phenotype. An individual heterozygous for a wild-type and a null allele will have an abnormal phenotype. Shine-Dalgarno sequence A portion of the ribosome binding site in prokaryotes, the Shine-Dalgarno sequence is a 6 nucleotide mRNA sequence just upstream from the start codon. It is important for ribosome binding and the initiation of translation. 1. (10 points) Compare and contrast chromatin associated with actively transcribed genes and chromatin associated with inactive genes (Name at least 3 differences between them). See lecture 13, slide 33. Each correct difference was assigned 3 pts; full credit was given when at least 3 clear differences were listed with no incorrect statements. Though it is listed on lecture 13, slide 33, credit was not given for a difference being gene activity vs no gene activity. This is stated directly in the question and credit is not given for restating what is stated in the question. This pedigree shows a family affected by an autosomal dominant genetic disease.
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