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Unformatted text preview: Molecular Genetics Exam 3, Thursday, Nov. 18 page 1 of 6 Name _________________________________________________________________ (3 points each) In each of the following questions there are two or more statements. One is true (generally, it is taken directly from your text or another source). The other(s) have been modified so as to be untrue or misleading. Circle or otherwise designate the correct statement. 1. A region of DNA unwound by RNA polymerase is called the transcription bubble. a) Within the transcription bubble, the nascent RNA chain remains base paired with the DNA template, forming a DNA-RNA hybrid. 2. When geneticists refer to the sequence of a gene, they usually mean a) the sequence of the RNA-like strand. 3. How do cells make a mature RNA from a gene whose mature mRNA sequence is interrupted by introns? The cells b) make a primary transcript containing both introns and exon and then remove introns by RNA splicing. 4. a) A strategy of splicing carried out by some eukaryotes, trans-splicing, joins the exon of one gene with the exon of another gene. 5. The effective concentration of transcription factor (as sensed by RNA polymerase at a promoter) is greatest when it is bound: b ) About 500 nucleotides from the promoter. 6. Exposed regions of DNA recognized by their hypersensitivity to DNase digestion b) are associated with active genes. 7) In the case of genomic imprinting b) the copy of a gene inherited by one parent but not the other is transcriptionally inactive. 8) RISC a) stands for RNA-induced silencing complex and mediates RNA interference 9) In contrast to transcriptional regulation, ubiquitination a ) swiftly acts to remove specific proteins in response to a regulatory signal 10. The Drosophila autoregulatory protein Sxl (Sex-lethal) a ) promotes its own synthesis through RNA splicing, resulting in a productive mRNA, thereby acting as a self-reinforcing on/off switch . Molecular Genetics Exam 3, Thursday, Nov. 18 page 2 of 6 Name _________________________________________________________________ 11. Autozygosity is a term used to refer to homozygosity a ) by descent from a common ancestor. 12. In classical genetics a ) A null allele is usually recessive to wild-type. 13. The modern concept of dominant negative most closely resembles the classic b ) antimorphic allele....
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