Molecular Genetics BSCI410
Homework 4; Lectures 1318
Homework due at the
beginning
of class on
Thursday, Nov. 11, 2010.
The exam will be Nov. 18.
Homework and review questions will be discussed at the review on Nov. 16.


1
Homework questions
. Please provide your answers on a separate sheet.
Examine the following pedigree.
A
1,2
B
1,2
A
1,3
B
1,3
A
1,2
B
1,2
A
1,2
B
1,3
1. (1 point) The A
1
alleles in the two brothers are identical by state (this just means that they are
both A
1
). Can you infer that they are also identical by descent?
a) You don't know whether or not A
1
is identical by descent.
b) You can conclude that A
1
is identical by descent.
c) You can conclude A
1
is not identical by descent.
2. (1 point) The B
1
alleles in the two brothers are identical by state (this just means that they are
both B
1
). Can you infer that they are also identical by descent?
a) You don't know whether or not B
1
is identical by descent.
b) You can conclude that B
1
is identical by descent.
c) You can conclude B
1
is not identical by descent.
(Questions 35) Consider two populations, 1 and 2, that differ at two
unlinked
loci, A and B. In
each population a specific allele is fixed at each locus (
i.e.
all individuals in population 1 are
homozygous for A
1
and B
1
 they have the genotype A
1,1
B
1,1
 while all individuals in
population 2 have the genotype A
2,2
B
2,2
).
You allow a large and equivalent number of individuals from the two populations  for example,
500 males and 500 females from population 1 and 500 males and 500 females from population 2 
to mate at random (and they do mate at random).
3. (1 point) Is locus A at HardyWeinberg equilibrium in the "G1" generation?
4. (1 point) What is the expected frequency of each of the four possible gametes transmitted from
the G1 to the G2. The possible genotypes are A
1
B
1
, A
1
B
2
, A
2
B
1
and A
2
B
2
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Molecular Genetics BSCI410
Homework 4; Lectures 1318
Homework due at the
beginning
of class on
Thursday, Nov. 11, 2010.
The exam will be Nov. 18.
Homework and review questions will be discussed at the review on Nov. 16.


2
5. (1 point) Do the two alleles A
1
and B
1
show genetic association (linkage disequilibrium) in this
G1 generation?
(Your answer can be "yes" or "no." It is not necessary to calculate an r
2
or D value).
6. Suppose you carry out a mapping cross between two parent strains P1 and P2 as described in
lecture 15, and you have 16 F2 individuals in your mapping population. The parent strains P1 and
P2 have numerous polymorphic differences between them. You assay 3 RFLP genetic markers (A,
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 Summer '08
 SAXENA
 Genetics, Molecular Genetics, Genetic linkage, LOD score

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