chapt17 - Chapter 17Gene Regulation in Eukaryotes Fill in...

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Chapter 17—Gene Regulation in Eukaryotes Fill in the Blank 1. ______________________ are encoded by DNA distant from the gene being regulated, and often function as DNA-binding proteins. Ans: Trans-acting factors (transcription factors) Difficulty: 1 2. ______________________ are DNA sequences, often found near the 5' end of the regulated gene, to which proteins bind, thus regulating the transcription of the gene. Ans: Cis-acting elements Difficulty: 1 3. Trans-acting factors that function to increase the level of expression of a gene are termed ___________________________. Ans: transcriptional activators Difficulty: 2 4. Trans-acting factors that function to decrease the level of expression of a gene are termed ___________________________. Ans: transcriptional repressors Difficulty: 2 5. The mechanism of transcriptional repression in which trans-acting repressor proteins bind to an activator protein, thus preventing the activator from activating transcription is termed __________________. Repressors that function using this mechanism mediate their effect by binding to either the ________________________ domain or _________________________ domain of the activator protein. Ans: quenching, Transcriptional activation, DNA-binding Difficulty: 3 6. A single strand of nucleotides that is complementary to an mRNA is termed a(n) ___________________ sequence. Ans: antisense Difficulty: 2 7. Numerator and denominator elements regulate sex-determination in Drosophila. If the ratio of numerator homodimers to numerator/denominator heterodimers is high, the ________________ gene will be expressed, generating a fly with ___________________ sexual characteristics. Ans: sxl, female Difficulty: 3 Page 57
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8. ______________________ is a small protein that is covalently attached to polypeptides in long chains, targeting the tagged peptide for degradation. The large, multienzyme complex that functions to degrade these tagged polypeptides is termed a ___________________. Ans: ubiquitin, proteosome Difficulty: 3 Multiple Choice 9. Transcription in prokaryotes and eukaryotes is similar in that: A) transcriptional machinery controls compaction and decompaction of chromatin. B) the mRNA produced can undergo alternative splicing. C) both prokaryotic and eukaryotic proteins have identical affinities for DNA. D) both are contained within the cell nucleus. E) both are regulated by attachment of proteins to DNA adjacent to the gene being transcribed. Ans: E Difficulty: 3 10. Most decisions controlling the amount of gene product synthesized are made during: A) termination of replication. B) transport of mRNA to the cytoplasm. C) initiation of transcription. D) alternative splicing. E) regulation of translation.
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chapt17 - Chapter 17Gene Regulation in Eukaryotes Fill in...

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