Exam 3 - keyed - BIO325 Genetics Instructor: Dr. Tracey...

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BIO325 Genetics Exam 3 Instructor: Dr. Tracey Ruhlman TA: Teofil Nakov MULTIPLE CHOICE 2 POINTS EACH: Please choose only one response, WRITE YOUR LETTER RESPONSE AT THE LEFT BELOW THE QUESTION NUMBER. 1) If you had a mutation affecting anterior-posterior patterning of the Drosophila embryo in which every other segment of the developing mutant larva was missing, would you consider it a mutation in: a) a gap gene b) a pair-rule gene c) a segment-polarity gene d) a segment-identity (i.e Hox ) gene e) cannot be deterimined from information given 2) The primary role(s) of Hox genes during normal Drosophila development is to: a) Form segments b) Determine the identity of segments c) Promote cell division d) Maintain functional homeostasis e) Establish anteroposterior axis 3) Ubx (Ultrabithorax) is a Drosophila homeotic gene that normally has two key functions: Promote hindwing development and repress forewing development. A nonlethal loss-of-function allele of Ubx might reasonably be expected to: a) Transform the forewing into a hindwing b) Transform the hindwing into a forewing c) Result in no development of either hindwing or forewing d) Result in growth of an eye structure instead of a wing structure
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e) Transform the forewing into a leg structure 4) The homeodomain found in all proteins encoded by Hox genes has what function? a) Binding RNA b) Binding histones c) Repressing transcription d) Binding DNA e) Targeting proteins for degradation 5) The expression of ‘tool kit’ genes is precisely modulated both spatially and temporally by the binding activities of a number of protein factors during the early development of animals. To achieve this level of control tool kit genes: a) Encode splicing enzymes that activate Hox mRNAs b) Contain regions composed of multiple activator and repressor elements that allow context specific control of expression c) Have strictly defined roles in the developmental process in a limited number of organisms d) Are sequentially ordered along the length of the chromosome, from largest to smallest e) Are insensitive to mutations that could modify developmental fate of a given tissue 6) The primary control point at which gene expression is regulated is initiation of: a) Transcription b) Splicing c) Nucleus-to-cytosol transport d) Translation e) Post-translational modification
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7) A homeotic mutation: a) Results in replacement of one normal body part with another. b) Produces unusual phenotypes due to gain-of-function or loss-of- function. c) May cause all segments to have the same identity. d) Affects both pairs of serially reiterated structures. e) All to the above 8) You wish to probe a human cDNA library to find out which insert has the β- globin gene. Which of the following would be a good choice as your probe (assume in all cases your probe is labeled)?
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Exam 3 - keyed - BIO325 Genetics Instructor: Dr. Tracey...

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